Tear proteome in uveitis
نویسندگان
چکیده
منابع مشابه
Update on Human Tear Proteome
Tear film is a thin layer of non-newtonian fluid covering and protecting cornea and conjunctiva epithelia. The multifaced functions of tears are reflected by their complex structure and advances in proteomics/metabolomics/lipidomics technologies have greatly deepened the knowledge of the chemical composition of tears. The purpose of this article is to survey recent advances in proteomic analysi...
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In this study, mass spectrometry was used to explore the canine tear proteome. Tear samples were obtained from six healthy dogs, and one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis (1D SDS-PAGE) was used as a first step to separate intact proteins into 17 bands. Each fraction was then trypsin digested and analysed by matrix-assisted laser desorption/ionization time-of...
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Vitrectomy was performed on 25 eyes in 21 patients with chronic uveitis from various etiologies. Postoperative follow up averaged 22.8 months with visual improvement in 24 of 25 eyes. In this retrospective study, the techniques employed and the beneficial effect of vitrectomy alone or vitrectomy combined with cataract surgery (Iensectomy in most cases) on improving vision and decreasing th...
متن کاملOn the tear proteome of the house mouse (Mus musculus musculus) in relation to chemical signalling
Mammalian tears are produced by lacrimal glands to protect eyes and may function in chemical communication and immunity. Recent studies on the house mouse chemical signalling revealed that major urinary proteins (MUPs) are not individually unique in Mus musculus musculus. This fact stimulated us to look for other sexually dimorphic proteins that may-in combination with MUPs-contribute to a pool...
متن کاملLacritin and the tear proteome as natural replacement therapy for dry eye.
Tear proteins are potential biomarkers, drug targets, and even biotherapeutics. As a biotherapeutic, a recombinant tear protein might physiologically rescue the ocular surface when a deficiency is detected. Such a strategy pays more attention to the natural prosecretory and protective properties of the tear film and seeks to alleviate symptoms by addressing cause, rather than the current pallia...
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ژورنال
عنوان ژورنال: Acta Ophthalmologica
سال: 2019
ISSN: 1755-375X,1755-3768
DOI: 10.1111/j.1755-3768.2019.8098